| Nintendo Famicom cart. |  Softball Tengoku | 1989 | Tonkin House Japan |
| Nintendo Famicom cart. | Solitair | 19?? | Unknown |
| Nintendo Famicom cart. | Solomon no Kagi 2 - Coolmin Tou Kyuushutsu Sakusen Model TCF-SZ-19 | 1992 | Tecmo, Ltd. Tokyo, Japan |
| Nintendo Famicom cart. | Solomon no Kagi Model TCF-SK P | 1986 | Tecmo, Ltd. Tokyo, Japan |
| Nintendo Famicom cart. |  Solstice - Sanjigen Meikyuu no Kyoujuu Model ESF-E3 | 1990 | Epic/Sony Records Sony Music Ent., Inc. Japan |
| Nintendo Famicom cart. | Son Son Model CAP-SS P | 1986 | Capcom Co., Ltd. Japan |
| Nintendo Famicom cart. | Sonic | 19?? | Unknown |
| Nintendo Famicom cart. | Sonic the Edgehog Sonic 3D Blast 5 | 199? | Unknown |
| Nintendo Famicom cart. | Soreike! Anpanman - Minna de Hiking Game! Model BAN-OZ | 1992 | Bandai Co., Ltd. Japan |
| Nintendo Famicom cart. | Space 2050 | 19?? | Unknown |
| Nintendo Famicom cart. | Space Boy | 19?? | Unknown |
| Nintendo Famicom cart. | Space Harrier Model TFC-SO P | 1989 | Takara Co., Ltd. Japan |
| Nintendo Famicom cart. | Space Hunter Model KSC-HT | 1986 | Kemco, Ltd. |
| Nintendo Famicom cart. | Space Invaders Model TF-4500 P | 1985 | Taito Corp. Japan |
| Nintendo Famicom cart. | Space Shadow | 1989 | Bandai Co., Ltd. Japan |
| Nintendo Famicom cart. | Spartan X 2 Model IF-23 | 1991 | Irem Corp. Japan |
| Nintendo Famicom cart. | Spartan X Model HVC-SX P | 1985 | Nintendo Co., Ltd. Japan |
| Nintendo Famicom cart. | Spelunker II - Yuusha e no Choosen Model IF-06 | 1987 | Irem Corp. Japan |
| Nintendo Famicom cart. | Spelunker Model IF-03 | 1985 | Irem Corp. Japan |
| Nintendo Famicom cart. | Splatterhouse - Wanpaku Graffiti Model NAM-FSH-4900 | 1989 | NAMCOT Japan |
| Nintendo Famicom cart. | Spot | 1992 | BPS Bullet-Proof Soft. Japan |
| Nintendo Famicom cart. | Spy vs Spy Model KSC-SP P | 1986 | Kemco, Ltd. |
| Nintendo Famicom cart. | Sqoon Model IF-04 | 1986 | Irem Corp. Japan |
| Nintendo Famicom cart. |  Square Deal | 1991 | HECT Hector Japan |
| Nintendo Famicom cart. | Square Force | 19?? | Unknown |
| Nintendo Famicom cart. | Square no Tom Sawyer | 1989 | Square Co., Ltd. Japan |
| Nintendo Famicom cart. | Star Evil Hb | 201? | Unknown |
| Nintendo Famicom cart. | Star Force Model HFC-SF P | 1985 | Hudson Soft. Hudson Group Japan |
| Nintendo Famicom cart. | Star Gate Model HAL-SB | 1987 | HAL Laboratory, Inc. Japan |
| Nintendo Famicom cart. | Star Luster Model NSL-4900 | 1985 | NAMCOT Japan |
| Nintendo Famicom cart. | Star Soldier - Special Version | 1986 | Hudson Soft. Hudson Group Japan |
| Nintendo Famicom cart. | Star Soldier Model SHVC-SO | 1986 | Hudson Soft. Hudson Group Japan |
| Nintendo Famicom cart. | Star Wars | 1987 | NAMCOT Japan |
| Nintendo Famicom cart. | Star Wars - The Empire Strikes Back | 1993 | JVC Musical Industries, Inc. |
| Nintendo Famicom cart. | Star Wars Model VFR-7V | 1991 | Victor Musical Industries, Inc. Japan |
| Nintendo Famicom cart. | STED - Iseki Wakusei no Yabou | 1990 | KAC K.Amusement Lising Co. Japan |
| Nintendo Famicom cart. | Stick Hunter - Exciting Ice Hockey Game | 1987 | KAC K.Amusement Lising Co. Japan |
| Nintendo Famicom cart. | Strategist Model TC-014 | 1991 | Sachen Thin Chen co. Taiwan |
| Nintendo Famicom cart. | Street Blaster II Pro | 1993 | Cony Soft |
| Nintendo Famicom cart. | Street Blaster IV Pro 10 | 1993 | Cony Soft |
