| Nintendo Famicom cart. |  Shikinjou Model TDF-96 | 1991 | Toei Animation Co., Ltd. Japan |
| Nintendo Famicom cart. | Shin 4-nin Uchi Mahjong - Yakuman Tengoku Model HVC-YT | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo Famicom cart. | Shin Jinrui - The New Type Model RES-SG | 1987 | Rix Soft. Japan |
| Nintendo Famicom cart. | Shin Moero!! Pro Yakyuu | 1989 | JALECO Co., Ltd. Japan |
| Nintendo Famicom cart. | Shin Satomi Hakkenden - Hikari to Yami no Tatakai Model TDF-91 | 1989 | Toei Animation Co., Ltd. Japan |
| Nintendo Famicom cart. | Shinsenden | 1989 | Irem Corp. Japan |
| Nintendo Famicom cart. | Shogun | 1988 | HECT Hector Japan |
| Nintendo Famicom cart. | Shoot Out | 19?? | Unknown |
| Nintendo Famicom cart. | Shoot UFO | 19?? | Unknown |
| Nintendo Famicom cart. | Shooter | 19?? | Unknown |
| Nintendo Famicom cart. | Shougi Meikan '92 | 1992 | HECT Hector Japan |
| Nintendo Famicom cart. | Shougi Meikan '93 | 1992 | HECT Hector Japan |
| Nintendo Famicom cart. | Shoukoushi Ceddie | 1988 | Fuji TV |
| Nintendo Famicom cart. | Shounen Ashibe - Nepal Daibouken no Maki | 1991 | Takara Co., Ltd. Japan |
| Nintendo Famicom cart. |  Shounen Majutsushi Indy | 1992 | IGS Corp. Information Global Service |
| Nintendo Famicom cart. | Shu Ma Bao Bei | 200? | Fuzhou Coolboy Electronics Co., Ltd. China |
| Nintendo Famicom cart. | Shu Ma Bao Long 4 - Shui Jing Ban | 19?? | Waixing Computer & Technology Co., Ltd. China |
| Nintendo Famicom cart. | Shu Ma Bao Long III Model NJ005 | 200? | Shenzhen Nanjing Technology Co., Ltd. China |
| Nintendo Famicom cart. | Shu Ma Zhan Dui II Model NJ006 | 200? | Shenzhen Nanjing Technology Co., Ltd. China |
| Nintendo Famicom cart. | Shuang Xiang Pao | 1988 | Bit Corp. |
| Nintendo Famicom cart. | Shuang Ying | 1989 | Sachen Thin Chen co. Taiwan |
| Nintendo Famicom cart. | Shuffle Fight | 1992 | Banpresto Japan |
| Nintendo Famicom cart. | Shufflepuck Cafe Model R62V10002 (PHF-XP) | 1990 | Pony Canyon, Inc. Japan |
| Nintendo Famicom cart. | Shui Guo Li | 1988 | Bit Corp. |
| Nintendo Famicom cart. | Shui Hu 3 Model NJ028 | 200? | Shenzhen Nanjing Technology Co., Ltd. China |
| Nintendo Famicom cart. | Shui Hu Shen Shou Model ES-1087 | 2004 | Waixing Computer & Technology Co., Ltd. China |
| Nintendo Famicom cart. | Shui Hu Shen Shou Model NJ019 | 2004 | Shenzhen Nanjing Technology Co., Ltd. China |
| Nintendo Famicom cart. | Shui Hu Zhuan Model ES-130 | 19?? | Waixing Computer & Technology Co., Ltd. China |
| Nintendo Famicom cart. | Si Lu Chuan Qi | 19?? | HengGedianzi China |
| Nintendo Famicom cart. | Side Pocket Model NAM-SP-3900 | 1987 | NAMCOT Japan |
| Nintendo Famicom cart. | Silva Saga | 1992 | Seta Co., Ltd. Japan |
| Nintendo Famicom cart. | Skiing | 19?? | Unknown |
| Nintendo Famicom cart. | Sky Destroyer Model TFC-SD-4500 | 1985 | Taito Corp. Japan |
| Nintendo Famicom cart. | Sky Kid Model NSK-3900 P | 1986 | NAMCOT Japan |
| Nintendo Famicom cart. | Snow Bros. | 1991 | Toaplan Co., Ltd. Tokyo, Japan |
| Nintendo Famicom cart. | Snowfield Shoot | 19?? | Unknown |
| Nintendo Famicom cart. | Soap Panic 18 | 1991 | Hacker International |
| Nintendo Famicom cart. | Soccer | 19?? | Unknown |
| Nintendo Famicom cart. | Soccer League - Winner's Cup | 1988 | Data East Corp. Japan |
| Nintendo Famicom cart. | Soccer Model HVC-SC | 1985 | Nintendo Co., Ltd. Japan |
