| Sega Genesis cart. |  NHL Hockey Model 7228 | 1991 | EA Sports |
| Sega Genesis cart. | Onslaught | 1991 | Ballistic |
| Sega Genesis cart. |  Out Run Model 1125 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Pac-Mania P | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | PGA Tour Golf Model 7002 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Phantasy Star III - Generations of Doom Model 1303 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Pit-Fighter Model 301027 | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Populous Model 7016 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Powerball Model T-14036 | 1991 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | Quad Challenge Model T14056 | 1991 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | R.B.I. Baseball 3 | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Raiden Trad P | 1991 | Micronet Co., Ltd. Japan |
| Sega Genesis cart. | Rampart | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Road Rash Model 7020 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | RoadBlasters Model 31763-03250 | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Rolling Thunder 2 Model T-14066 P | 1991 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | Romance of the Three Kingdoms II Model T-76016 | 1991 | KOEI Corp. CA, USA |
| Sega Genesis cart. | Sagaia Model 11016 | 1991 | Taito Corp. Japan |
| Sega Genesis cart. | Saint Sword | 1991 | Taito America Corp. Elk Grove Village, IL, USA |
| Sega Genesis cart. | Shadow of the Beast Model 7091 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Shining in the Darkness Model 1310 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Slaughter Sport | 1991 | Razorsoft, Inc. Oklahoma City, OK, USA |
| Sega Genesis cart. | Sonic the Hedgehog Model 1009-22 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sonic the Hedgehog Model 1009 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Space Invaders '91 | 1991 | Taito America Corp. Elk Grove Village, IL, USA |
| Sega Genesis cart. | Speedball 2 - Brutal Deluxe Model T-69026 | 1991 | Arena Ent. |
| Sega Genesis cart. | Spider-Man vs the Kingpin Model 1016 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Star Control | 1991 | Ballistic |
| Sega Genesis cart. | Street Smart Model T-24026 P | 1991 | TRECO USA |
| Sega Genesis cart. | Streets of Rage | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Super Volleyball | 1991 | Video System Co., Ltd. Kyoto, Japan |
| Sega Genesis cart. | Swamp Thing | 1991 | NuVision |
| Sega Genesis cart. | T2 - Terminator 2 - Judgment Day | 1991 | Flying Edge |
| Sega Genesis cart. | Task Force Harrier EX | 1991 | TRECO USA |
| Sega Genesis cart. | The Faery Tale Adventure Model 7056 P | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | The Terminator | 1991 | Virgin Games, Ltd. UK 013715 |
| Sega Genesis cart. | Thunder Fox | 1991 | Taito Corp. Japan |
| Sega Genesis cart. | Todd's Adventures in Slime World Model T-49216 | 1991 | Renovation Products USA |
| Sega Genesis cart. | Toe Jam & Earl Model 1020 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Trouble Shooter | 1991 | Vic Tokai Japan |
