| Sega Mega Drive cart. |  Starflight | 1991 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Street Smart Model T-24083 P | 1991 | TRECO |
| Sega Mega Drive cart. |  Streets of Rage | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Streets of Rage | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Strider | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Strider | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Super Airwolf Model T-29013 | 1991 | Kyugo Japan |
| Sega Mega Drive cart. | Super Hydlide Model 670-2048-03 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Super Monaco GP | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Super Volley Ball Model T-30013 | 1991 | Video System Co., Ltd. Kyoto, Japan |
| Sega Mega Drive cart. | Sword of Sodan Model G-4056 P | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Talmit's Adventure | 1991 | NAMCO, Ltd. Japan |
| Sega Mega Drive cart. | Task Force Harrier EX Model T-24053 | 1991 | TRECO |
| Sega Mega Drive cart. | The Revenge of Shinobi | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | The Terminator | 1991 | Virgin Games, Ltd. UK 013715 |
| Sega Mega Drive cart. | Thunder Fox Model T-11113 | 1991 | Taito Corp. Japan |
| Sega Mega Drive cart. | Toe Jam & Earl | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Toe Jam & Earl | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Turrican | 1991 | Ballistic |
| Sega Mega Drive cart. | Uchuu Senkan Gomora Model T-42023 P | 1991 | UPL Co., Ltd. Universal PlayLand |
| Sega Mega Drive cart. | UndeadLine Model T-74013 | 1991 | Palsoft |
| Sega Mega Drive cart. | Valis III Model T-49023 | 1991 | Renovation Products USA |
| Sega Mega Drive cart. | Verytex Model T-20043 | 1991 | Asmik Co., Ltd. Japan |
| Sega Mega Drive cart. | Volfied Model T-11103 | 1991 | Taito Corp. Japan |
| Sega Mega Drive cart. | Wardner no Mori Special Model T-58013 P | 1991 | Visco Corp. Kyoto, Japan |
| Sega Mega Drive cart. | Wonder Boy III - Monster Lair | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Wonder Boy V - Monster World III Model G-5509 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Wrestle War Model 1206-50 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Wrestle War Model G-4055 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Wrestleball Model T-14043 | 1991 | NAMCOT Japan |
| Sega Mega Drive cart. | Ys - Wanderers from Ys Model T-49063 | 1991 | Riot Japan |
| Sega Mega Drive cart. | Zan - Yasha Enbukyoku Model T-32033 | 1991 | Wolf Team Japan |
| Sega Mega Drive cart. | Zero Wing Model T-40023 P | 1991 | Toaplan Co., Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | A Ressha de Ikou MD - Take the A Train Model G-4532 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Air Management - Oozora ni Kakeru Model T-76083 | 1992 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | Alisia Dragoon Model 1039-50 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Alisia Dragoon Model T-45033 | 1992 | Game Arts Co., Ltd. Japan |
| Sega Mega Drive cart. | Andre AGASSI Tennis Model 043300 | 1992 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Andre AGASSI Tennis Model T-101016-50 | 1992 | TecMagik Ent., Ltd. |
| Sega Mega Drive cart. | Arch Rivals - The Arcade Game Model T-81056-50 | 1992 | Flying Edge |
