| Commodore Amiga 500 disk |  Speedball | 1988 | Image Works |
| Commodore Amiga 500 disk | Speedball | 1988 | Spotlight Soft. |
| Commodore Amiga 500 disk | Spidertronic | 1988 | Ere Informatique Paris, France |
| Commodore Amiga 500 disk | Spinworld | 1988 | ReLINE |
| Commodore Amiga 500 disk | Star Goose! | 1988 | Logotron, Ltd. |
| Commodore Amiga 500 disk | Star Wars | 1988 | Domark Group, Ltd. |
| Commodore Amiga 500 disk | Star Wars - Return of the Jedi Model 346-8 | 1988 | Domark Group, Ltd. |
| Commodore Amiga 500 disk | Star Wars - The Empire Strikes Back Model 320-? | 1988 | Domark Group, Ltd. |
| Commodore Amiga 500 disk | Starglider 2 - The Egrons Strike Back Model 108115 | 1988 | Rainbird Soft. UK 012439 |
| Commodore Amiga 500 disk | StarRay | 1988 | Logotron, Ltd. |
| Commodore Amiga 500 disk | Starways | 1988 | Diamond Robtek label |
| Commodore Amiga 500 disk | Street Fighter | 1988 | GO! Media Holdings, Ltd. 13442 |
| Commodore Amiga 500 disk | Strike Force Harrier | 1988 | Mirrorsoft, Ltd. England |
| Commodore Amiga 500 disk |  Strike Force Harrier | 1988 | Mirror Image Soft. |
| Commodore Amiga 500 disk | Strip Poker II | 1988 | Anco Soft., Ltd. |
| Commodore Amiga 500 disk | Strip Poker II+ | 1988 | Anco Soft., Ltd. |
| Commodore Amiga 500 disk | Sub Battle Simulator | 1988 | Epyx, Inc. Redwood City, CA, USA |
| Commodore Amiga 500 disk | Suicide Mission | 1988 | Prism Leisure Corp. plc UK 014293 |
| Commodore Amiga 500 disk | Super Hang-On P | 1988 | Electric Dreams Soft. |
| Commodore Amiga 500 disk | Superstar Ice Hockey | 1988 | Databyte |
| Commodore Amiga 500 disk | Sword of Sodan | 1988 | Discovery Soft. |
| Commodore Amiga 500 disk | Tanglewood | 1988 | Microdeal |
| Commodore Amiga 500 disk | Techno Cop | 1988 | Gremlin Graphics Soft., Ltd. 013658 |
| Commodore Amiga 500 disk | Teenage Queen | 1988 | Ere Informatique Paris, France |
| Commodore Amiga 500 disk | The Armageddon Man | 1988 | Martech Games, Ltd. |
| Commodore Amiga 500 disk | The Bard's Tale II - The Destiny Knight Model 1313 | 1988 | Electronic Arts CA, USA 14633 |
| Commodore Amiga 500 disk | The Deep | 1988 | US Gold, Ltd. Birmingham, England 13442 |
| Commodore Amiga 500 disk | The Final Mission | 1988 | ReLINE |
| Commodore Amiga 500 disk | The Flintstones | 1988 | Grandslam Ent., Ltd. |
| Commodore Amiga 500 disk | The Great Giana Sisters | 1988 | GO! Media Holdings, Ltd. 13442 |
| Commodore Amiga 500 disk | The Great Giana Sisters Model 000411 | 1988 | Time Warp |
| Commodore Amiga 500 disk | The Guild of Thieves Model 006312 | 1988 | Rainbird Soft. UK 012439 |
| Commodore Amiga 500 disk | The Pioneer Plague | 1988 | Mandarin Soft. |
| Commodore Amiga 500 disk | The President is Missing | 1988 | MicroProse, Ltd. Bristol, UK 015352 |
| Commodore Amiga 500 disk | The Real Ghostbusters | 1988 | Activision, Inc. Menlo Park, CA, USA 47875 |
| Commodore Amiga 500 disk | The Sentinel Model 011705 | 1988 | Firebird Soft. UK 012439 |
| Commodore Amiga 500 disk | The Twilight Zone | 1988 | First Row |
| Commodore Amiga 500 disk | Thexder | 1988 | Sierra On-Line, Inc. USA 20626 |
| Commodore Amiga 500 disk | Thunder Blade P | 1988 | US Gold, Ltd. Birmingham, England 13442 |
| Commodore Amiga 500 disk | ThunderCats | 1988 | Elite Systems, Ltd. |
