| Nintendo Game Boy Color cart. |  Disney's Tarzan Model CGB-BTHJ-JPN | 2000 | Syscom Ent. Japan |
| Nintendo Game Boy Color cart. | Disney's The Emperor's New Groove Model CGB-BENE-USA | 2000 | UBI Soft Ent., Inc. San Francisco, CA, USA 08888 |
| Nintendo Game Boy Color cart. | Disney's The Little Mermaid II - Pinball Frenzy Model CGB-BY2P-EUR | 2000 | Disney Interactive |
| Nintendo Game Boy Color cart. | Disney's The Little Mermaid II - Pinball Frenzy Model CGB-VM2E-USA | 2000 | Disney Interactive |
| Nintendo Game Boy Color cart. |  Dogz - Your Virtual Petz Palz Model CGB-AOZP-EUR | 2000 | Mindscape International West Sussex, England |
| Nintendo Game Boy Color cart. | Dokapon! Millennium Quest Model DMG-BDKJ-JPN | 2000 | Asmik Ace Ent., Inc. Japan |
| Nintendo Game Boy Color cart. | Dokidoki Densetsu - Mahoujin Guruguru Model CGB-B96J-JPN | 2000 | Enix, Ltd. Japan |
| Nintendo Game Boy Color cart. | Donkey Kong 5 | 2000 | Yong Yong China |
| Nintendo Game Boy Color cart. |  Donkey Kong Country demo | 2000 | Nintendo of America, Inc. USA 45496 |
| Nintendo Game Boy Color cart. | Donkey Kong Country Model CGB-BDDE-USA | 2000 | Nintendo of America, Inc. USA 45496 |
| Nintendo Game Boy Color cart. | Donkey Kong Country Model CGB-BDDP-AUS | 2000 | Nintendo Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Donkey Kong Country Model CGB-BDDP-EUR | 2000 | Nintendo of Europe GmbH 45496 |
| Nintendo Game Boy Color cart. | Donkey Kong GB - Dinky Kong & Dixie Kong Model CGB-AD3J-JPN | 2000 | Nintendo Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Doraemon Memories - Nobita no Omoide Daibouken Model DMG-BDMJ-JPN | 2000 | Epoch Co., Ltd. Tokyo, Japan |
| Nintendo Game Boy Color cart. | Doraemon no Quiz Boy Model CGB-BQBJ-JPN | 2000 | Shogakukan Production |
| Nintendo Game Boy Color cart. | Doraemon no Study Boy - Kuku Game Model CGB-BQQJ-JPN | 2000 | Shogakukan Production |
| Nintendo Game Boy Color cart. | Dragon Dance Model DMG-BDAE-USA | 2000 | Crave Ent., Inc. |
| Nintendo Game Boy Color cart. | Dragon Quest III - Soshite Densetsu he... Model CGB-BD3J-JPN | 2000 | Enix, Ltd. Japan |
| Nintendo Game Boy Color cart. | Dragon Quest Monsters Model DMG-AWQD-NOE | 2000 | Eidos Interactive |
| Nintendo Game Boy Color cart. | Dragon Tales - Dragon Wings Model CGB-BDZE-USA | 2000 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | Dragon Tales - Dragon Wings Model CGB-BDZP-EUR | 2000 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | Dragon Warrior I & II Model DMG-AEDE-USA | 2000 | Enix, Ltd. Japan |
| Nintendo Game Boy Color cart. | Driver Model CGB-BDRE-USA | 2000 | Infogrames Ent., Inc. CA, USA 20295 |
| Nintendo Game Boy Color cart. | Driver Model CGB-BDRP-EUU | 2000 | Infogrames Europe 546430 |
| Nintendo Game Boy Color cart. | Drymouth | 2000 | Demiforce |
| Nintendo Game Boy Color cart. | Dungeon Savior Model DMG-ADWJ-JPN | 2000 | J-Wing |
| Nintendo Game Boy Color cart. | DX Monopoly GB Model DMG-BMPJ-JPN | 2000 | Takara Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | ECW Hardcore Revolution Model CGB-BECE-USA | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo Game Boy Color cart. | ECW Hardcore Revolution Model CGB-BECP-EUR | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo Game Boy Color cart. | Elemental Tale - Jack no Daibouken - Daimaou no Gyakushuu Model DMG-AQJJ-JPN | 2000 | Imagineer Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Elevator Action EX Model CGB-BEXJ-JPN | 2000 | Altron Corp. |
| Nintendo Game Boy Color cart. | Elevator Action EX Model CGB-BEXP-EUR | 2000 | TDK Recording Media Europe S.A. |
| Nintendo Game Boy Color cart. | Elie no Atelier GB Model DMG-A8EJ-JPN | 2000 | Imagineer Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | ESPN International Track & Field Model CGB-B3HE-USA | 2000 | Konami Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Extreme Sports with the Berenstain Bears Model CGB-BESE-USA | 2000 | Sound Source Interactive, Inc. |
| Nintendo Game Boy Color cart. | Extreme Sports with the Berenstain Bears Model CGB-BESP-EUR | 2000 | Sound Source Interactive, Inc. |
| Nintendo Game Boy Color cart. | F-1 World Grand Prix Model CGB-AFIP-EUR | 2000 | Video System Co., Ltd. Kyoto, Japan |
| Nintendo Game Boy Color cart. | F-18 Thunder Strike Model CGB-B18E-USA | 2000 | Majesco Sales, Inc. |
| Nintendo Game Boy Color cart. | F-18 Thunder Strike Model CGB-B18P-NOE | 2000 | Majesco Sales, Inc. |
| Nintendo Game Boy Color cart. | F1 Championship Season 2000 | 2000 | EA Sports |
