| Microsoft XBOX 360 disc |  Rock Band 3 | 2010 | MTV Games |
| Sony PlayStation 3 disc | Rock Band 3 Model BLES-00986 | 2010 | MTV Games |
| Nintendo Wii disc | Rock Band 3 Model RVL-SZBE-USA | 2010 | MTV Games |
| Nintendo Wii disc |  Rock Band 3 Model RVL-SZBP-EUR | 2010 | MTV Games |
| Apple Store pack. | Rock Band Reloaded | 2010 | Unknown |
| Video Slot Machine |  Rock Climber | 2010 | Igrosoft |
| RCA Studio II cart. | Rocket P Hb | 2010 | Romanow, Lee |
| PC/MS-Windows CD | Rocket Knight | 2010 | Konami Digital Ent. Co., Ltd. |
| Sony PSN: Shodai PS Archives pack. | Rockman 3 - Dr. Wily no Saigo!? Model NPJI-????? | 2010 | Capcom Co., Ltd. Japan |
| Slot Machine | Roma | 2010 | Top Counter Barcelona, Spain |
| Slot Machine | Romeo & Juliet | 2010 | IGT International Game Technologies Reno, NV, USA |
| Sony PlayStation 3 disc | Rorona no Atelier - Arland no Renkinjutsushi Model BLJM-55018 | 2010 | Gust Japan |
| Slot Machine | Royal Diamonds Double Hit Game Plus | 2010 | Ainsworth Game Technology, Ltd. |
| Slot Machine | Royal Race Course | 2010 | AGT Advanced Games Technology Taiwan |
| Slot Machine | Royal Riverboat Run | 2010 | Atronic |
| Slot Machine | Royal Treasures Deluxe | 2010 | AGI Austrian Gaming Industries Novomatic Group |
| Apple Store pack. | rRootage Online HD | 2010 | Unknown |
| Belogic Uzebox ROM | Ruby Crush Hb | 2010 | Belogic |
| Slot Machine | Ruby Reels Spinning Reel | 2010 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Ruby Rush | 2010 | Bally Tech., Inc. |
| Slot Machine | Ruby Saloon | 2010 | Aristocrat Leisure Industries Pty, Ltd. |
| Apple Store pack. | Rugby Nations 2010 | 2010 | Unknown |
| Sony PSN: Shodai PS Archives pack. | Rung Rung - Oz no Mahou Tsukai - Another World Model NPJJ-00442 | 2010 | GungHo Online Ent. |
| Slot Machine | Ruusu | 2010 | Ray Espoo, Finland |
| Sony PlayStation 3 disc | Ryu ga Gotoku 4 - Densetsu o Tsugumono Model BLJM-60208 | 2010 | SEGA Corp. |
| Arcade Video game | Sabin Sound Star | 2010 | 3S Ent. |
| Arcade Video game | Sabin Sound Star - Renascence Burst | 2010 | 3S Ent. |
| Sony PlayStation 3 disc | Sacred 2 - Fallen Angel Model BLJS-10071 | 2010 | Spike Japan |
| Slot Machine | Saguaro | 2010 | IGT International Game Technologies Reno, NV, USA |
| Sony PSN: Shodai PS Archives pack. | Saikyo Ginsei Chess Model NPJI-????? | 2010 | Hamster Japan |
| Sony PSN: Shodai PS Archives pack. | Saikyo Ginsei Mahjong Model NPJI-????? | 2010 | Hamster Japan |
| Sony PSN: Shodai PS Archives pack. | Saikyo Ginsei Shogi 2 Model NPJI-????? | 2010 | Hamster Japan |
| Apple Store pack. | Sailboat Championship | 2010 | Unknown |
| Slot Machine | Saiyuki | 2010 | AGT Advanced Games Technology Taiwan |
| Sony PSN: Shodai PS Archives pack. | Salaryman Champ - Tatakau Salaryman Model NPJI-????? | 2010 | Hamster Japan |
| Slot Machine | Samba Parade | 2010 | Orion Gaming |
| Apple Store pack. | Samurai II - Dojo | 2010 | Unknown |
| Apple Store pack. | Samurai II - Vengeance | 2010 | Unknown |
| Arcade Video game | Sangokushi Taisen 3 - War Begins | 2010 | SEGA Corp. |
| Pachislot | SanSan Oasis 25-Pai | 2010 | Pioneer Co., Ltd. Japan |
