| PC/MS-Windows CD |  Endless Space 2 | 2017 | SEGA Corp. |
| PC/MS-Windows CD | Endorfun | 1995 | Time Warner Interactive |
| PC/MS-Windows CD | EndWar | 2009 | Ubisoft Ent. Montreuil sous Bois, France |
| PC/MS-Windows CD | Enemy Engaged - Apache/Havoc | 1998 | Empire Interactive Europe, Ltd. |
| PC/MS-Windows CD | Enemy Infestation | 1998 | Ripcord Games |
| PC/MS-Windows CD | Enemy Territory - Quake Wars | 2007 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| PC/MS-Windows CD | Enemy Zero | 1998 | SEGA Enterprises, Ltd. Tokyo, Japan |
| PC/MS-Windows CD | Enigmatic School | 1998 | Himeya Soft., Inc. Japan |
| PC/MS-Windows CD | Enslaved | 2013 | NAMCO Bandai Games, Inc. Japan |
| PC/MS-Windows CD | Enter the Matrix | 2003 | Atari Interactive, Inc. |
| PC/MS-Windows CD | Entomorph - Plague of The Darkfall | 1995 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| PC/MS-Windows CD | Eojjeonji Joheun Il-i Saenggil Geot Gateun Jeonyeok | 1998 | Korea Media Link |
| PC/MS-Windows CD | Eol-ui Hwansang-ui Seom Guchul Jakjeon | 1998 | Family Production, Inc. |
| PC/MS-Windows CD | Epic Mickey 2 - The Power of Two | 2012 | Disney Interactive |
| PC/MS-Windows CD | ER | 2005 | Vivendi Universal Games, Inc. |
| PC/MS-Windows CD | Eragon | 2006 | Sierra Ent., Inc. USA |
| PC/MS-Windows CD | Eraser - Turnabout | 1996 | Infogrames Interactive, Inc. 329720 |
| PC/MS-Windows CD | Erotica Island | 2002 | CDV Soft. Ent. USA, Inc. |
| PC/MS-Windows CD | Eryner | 1997 | Multi Plus Korea |
| PC/MS-Windows CD | Escape | 1999 | May-Be Soft. Japan |
| PC/MS-Windows CD | Escape from Monkey Island | 2000 | LucasArts Ent. Co. |
| PC/MS-Windows CD | Escape from Paradise City | ???? | TopWare Interactive AG |
| PC/MS-Windows CD | Esper | 1998 | HIC Infocomm Korea |
| PC/MS-Windows CD | Ether Vapor Re | 2012 | Capcom Ent., Inc. USA 13388 |
| PC/MS-Windows CD | Etherium | 2015 | Focus Home Interactive S.A.S. |
| PC/MS-Windows CD | Etherlords II | 2003 | Strategy First |
| PC/MS-Windows CD | Etrom - The Astral Essence | 2006 | Strategy First |
| PC/MS-Windows CD | Eunsaek-ui Yongbyeong | 1998 | HiCom Korea |
| PC/MS-Windows CD | Euratchacha Mu Daeri P | 2003 | Wizard Soft Korea |
| PC/MS-Windows CD | Euro 2000 | 2000 | Electronic Arts CA, USA 14633 |
| PC/MS-Windows CD | Euro Power Pack: The Ultimate Windows Game Collection Sw | 1995 | Euro Power Pack A/S |
| PC/MS-Windows CD | Eurofighter Typhoon | 2001 | KOCH Media Deutschland GmbH |
| PC/MS-Windows CD | Europa Universalis - Crown of the North | 2000 | Paradox Interactive |
| PC/MS-Windows CD | Europa Universalis - Rome | 2008 | Paradox Interactive |
| PC/MS-Windows CD | Europa Universalis II | 2001 | Strategy First |
| PC/MS-Windows CD | Europa Universalis III | 2007 | Paradox Interactive |
| PC/MS-Windows CD | Europa Universalis III - Divine Wind | 2010 | Paradox Interactive |
| PC/MS-Windows CD | Europa Universalis III - Heir to the Throne | 2009 | Paradox Interactive |
| PC/MS-Windows CD | Europa Universalis III - In Nomine | 2008 | Paradox Interactive |
| PC/MS-Windows CD | Europa Universalis III - Napoleon's Ambition | 2007 | Paradox Interactive |
