| Nintendo NES cart. |  Soccer | 1987 | Nintendo of America, Inc. USA 45496 |
| Nintendo NES cart. | Soccer Model NES-SC-NOE | 1985 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solar Jetman - Hunt for the Golden Warpship Model NES-LJ-EEC | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solar Jetman - Hunt for the Golden Warpship Model NES-LJ-UKV | 1990 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. |  Solar Jetman - Hunt for the Golden Warpship Model NES-LJ-USA | 1990 | Tradewest, Inc. Corsicana, TX, USA |
| Nintendo NES cart. | Solar Jetman - La Chasse au Vaisseau d'Or Model NES-LJ-FRA | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solar Wars Hb | 2001 | CMC Games |
| Nintendo NES cart. | Solaris Model RET-SL-GBL Hb | 2016 | RetroUSB |
| Nintendo NES cart. | Solitaire | 1992 | American Video Ent., Inc. Burlingame, CA, USA |
| Nintendo NES cart. | Solomon's Key 2 | 1993 | Tecmo, Ltd. Tokyo, Japan |
| Nintendo NES cart. | Solomon's Key Model NES-KE-EEC | 1990 | Tecmo, Ltd. Tokyo, Japan |
| Nintendo NES cart. | Solomon's Key Model NES-KE-USA | 1987 | Tecmo, Inc. CA, USA |
| Nintendo NES cart. | Solstice - La Quete du Sceptre de Denunos Model NES-LX-FRA | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solstice - The Quest for the Staff of Demnos Model NES-LX-FRG | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solstice - The Quest for the Staff of Demnos Model NES-LX-USA | 1990 | CSG Imagesoft |
| Nintendo NES cart. | Space Shuttle Project Model NES-6A-USA | 1991 | Absolute Ent., Inc. Midland Park, NJ, USA |
| Nintendo NES cart. | Spacey McRacey Hb | 201? | Bite the Chili Productions |
| Nintendo NES cart. | Spacy Shooty Hb | 2015 | Fraker, Doug |
| Nintendo NES cart. | Spelunker Model NES-SU-USA | 1987 | Broderbund Soft., Inc. CA, USA 47956 |
| Nintendo NES cart. | Spider-Man - Return of the Sinister Six Model NES-RX-AUS | 1992 | LJN, Ltd. |
| Nintendo NES cart. | Spider-Man - Return of the Sinister Six Model NES-RX-ESP | 1992 | LJN, Ltd. |
| Nintendo NES cart. | Spider-Man - Return of the Sinister Six Model NES-RX-FRA | 1992 | LJN, Ltd. |
| Nintendo NES cart. | Spider-Man - Return of the Sinister Six Model NES-RX-NOE | 1992 | LJN, Ltd. |
| Nintendo NES cart. | Spider-Man - Return of the Sinister Six Model NES-RX-UKV | 1992 | LJN, Ltd. |
| Nintendo NES cart. | Spider-Man - Return of the Sinister Six Model NES-RX-USA | 1992 | LJN, Ltd. |
| Nintendo NES cart. | Spiritual Warfare | 1992 | Wisdom Tree, Inc. CA, USA |
| Nintendo NES cart. | Spot Model NES-3P-USA | 1990 | Arcadia Systems, Inc. Mastertronic Group Costa Mesa, CA, USA |
| Nintendo NES cart. | Spy Hunter Model NES-HU P | 1987 | SUNSOFT Sun Corp. of America IL, USA |
| Nintendo NES cart. | Spy vs Spy Model NES-SP-USA P | 1988 | Kemco-Seika USA |
| Nintendo NES cart. | Sqoon Model NES-SQ-USA | 1987 | Irem Corp. Japan |
| Nintendo NES cart. |  Squashed | 1991 | JALECO Co., Ltd. Japan |
| Nintendo NES cart. | Stack-Up Model NES-SK-USA | 1985 | Nintendo of America, Inc. USA 45496 |
| Nintendo NES cart. | Stadium Events Model NES-SD-USA | 1987 | Bandai America, Inc. 45557 |
| Nintendo NES cart. | Stanley - The Search for Dr. Livingston Model NES-SS-USA | 1992 | Electro Brain Corp. |
| Nintendo NES cart. | Star Force Model NES-FO-USA | 1987 | Tecmo, Inc. CA, USA |
| Nintendo NES cart. | Star Soldier Model NES-SO-USA | 1989 | Taxan USA Corp. |
| Nintendo NES cart. | Star Trek - 25th Anniversary Model NES-8Z-USA | 1992 | Ultra Games Ultra Soft. Corp. |
| Nintendo NES cart. | Star Trek - The Next Generation Model NES-NX-USA | 1993 | Absolute Ent., Inc. Midland Park, NJ, USA |
| Nintendo NES cart. | Star Trek V - The Final Frontier | 1989 | Bandai America, Inc. 45557 |
| Nintendo NES cart. | Star Versus Hb | 2015 | Studio Dustmop |
