| Nintendo NES cart. |  Shinobi | 1989 | Tengen, Inc. Milpilas, CA, USA |
| Nintendo NES cart. | Shockwave | 1990 | AGCI American Game Cartridges, Inc. USA |
| Nintendo NES cart. | Shooting Range Model NES-ZS-USA | 1989 | Bandai America, Inc. 45557 |
| Nintendo NES cart. | Siamond Hb | 2008 | Sivak Games |
| Nintendo NES cart. |  Side Pocket Model NES-PK-USA | 1987 | Data East Corp. Japan |
| Nintendo NES cart. | Sidewinder | 1989 | HES Home Ent. Suppliers Sydney, Australia |
| Nintendo NES cart. | Sidewinder - Xiang Wei She Model TC-003 | 1989 | Sachen Thin Chen co. Taiwan |
| Nintendo NES cart. | Sidwinder | 1990 | Milmar |
| Nintendo NES cart. | Silent Assault | 1990 | Color Dreams, Inc. Brea, CA, USA |
| Nintendo NES cart. | Silent Assault Model TC-005 | 1990 | Sachen Thin Chen co. Taiwan |
| Nintendo NES cart. | Silent Service | 1990 | Konami Industry Co., Ltd. Japan |
| Nintendo NES cart. | Silent Service Model NES-IV-USA | 1989 | Ultra Games Ultra Soft. Corp. |
| Nintendo NES cart. | Silkworm Model NES-LK-USA | 1990 | American Sammy Corp. Torrance, CA, USA |
| Nintendo NES cart. | Silver Eagle Model TC-025 | 1993 | Sachen Thin Chen co. Taiwan |
| Nintendo NES cart. | Silver Surfer Model NES-VQ-USA | 1990 | Arcadia Systems, Inc. Mastertronic Group Costa Mesa, CA, USA |
| Nintendo NES cart. |  SimCity | 1991 | Nintendo of America, Inc. USA 45496 |
| Nintendo NES cart. | Sinking Feeling Hb | 2017 | Mega Cat Studios |
| Nintendo NES cart. |  Six in One | 1992 | Myriad Games, Inc. |
| Nintendo NES cart. | Skate Boy | 1992 | Gluk Video |
| Nintendo NES cart. | Skate or Die 2 - The Search for Double Trouble Model NES-E4-USA | 1990 | Electronic Arts CA, USA 14633 |
| Nintendo NES cart. | Skate or Die! | 1990 | Palcom Soft., Ltd. |
| Nintendo NES cart. | Skate or Die! Model NES-DI-USA | 1988 | Ultra Games Ultra Soft. Corp. |
| Nintendo NES cart. | Ski or Die | 1991 | Palcom Soft., Ltd. |
| Nintendo NES cart. | Ski or Die Model NES-7S-USA | 1991 | Ultra Games Ultra Soft. Corp. |
| Nintendo NES cart. | Sklad Nomer 18 | 1997 | Unknown Russia |
| Nintendo NES cart. | Skull & Crossbones | 1990 | Tengen, Inc. Milpilas, CA, USA |
| Nintendo NES cart. | Sky Kid Model NES-SY-USA | 1987 | SUNSOFT Sun Corp. of America IL, USA |
| Nintendo NES cart. | Sky Shark Model NES-2S-USA | 1989 | Taito America Corp. Elk Grove Village, IL, USA |
| Nintendo NES cart. | Slalom Model NES-SL-USA | 1987 | Nintendo of America, Inc. USA 45496 |
| Nintendo NES cart. | Slappin Bitches Hb | 2011 | Right Nut Games |
| Nintendo NES cart. | Smash T.V. Model NES-5V-USA P | 1991 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo NES cart. | Snail Maze Game Hb | 201? | Sly Dog Studios |
| Nintendo NES cart. | Snake Game Hb | 2012 | Axi |
| Nintendo NES cart. | Snake Rattle 'n Roll Model NES-RJ-USA | 1990 | Nintendo of America, Inc. USA 45496 |
| Nintendo NES cart. | Snake's Revenge | 1992 | Konami Co., Ltd. Japan |
| Nintendo NES cart. | Snake's Revenge Model NES-E2-USA | 1990 | Ultra Games Ultra Soft. Corp. |
| Nintendo NES cart. | Sneak'n Peek Model KHG-SP-GBL Hb | 2010 | RetroZone |
| Nintendo NES cart. | Snoopy's Silly Sports Spectacular! Model NES-OP-USA | 1990 | Kemco-Seika USA |
| Nintendo NES cart. | Snow Brothers Model NES-7L-USA | 1991 | Capcom USA, Inc. Santa Clara, CA, USA 13388 |
| Nintendo NES cart. | Snowboard Challenge | 1990 | Activision, Inc. Menlo Park, CA, USA 47875 |
