| Nintendo NES cart. |  Rock'n Ball Model NES-R4-USA | 1990 | NTVIC NTV International Corp. |
| Nintendo NES cart. |  Rocket Ranger Model NES-2R-USA P | 1990 | Kemco-Seika USA |
| Nintendo NES cart. | Rockin' Kats Model NES-7A-USA | 1991 | Atlus Soft., Inc. CA, USA |
| Nintendo NES cart. | Rod Land | 1993 | Storm Soft. |
| Nintendo NES cart. | Roger Clemens' MVP Baseball Model NES-6V-USA | 1991 | LJN, Ltd. |
| Nintendo NES cart. | Rollerball Model NES-RH-USA | 1990 | HAL Laboratory, Inc. Japan |
| Nintendo NES cart. | Rollerblade Racer Model NES-R6-USA | 1993 | Hi-Tech Expressions, Inc. |
| Nintendo NES cart. | Rollergames | 1991 | Konami Industry Co., Ltd. Japan |
| Nintendo NES cart. | Rollergames Model NES-U5-USA | 1990 | Ultra Games Ultra Soft. Corp. |
| Nintendo NES cart. | Rolling Thunder | 1989 | Tengen, Inc. Milpilas, CA, USA |
| Nintendo NES cart. | Romance of the Three Kingdoms II Model NES-XL-USA | 1991 | KOEI Corp. CA, USA |
| Nintendo NES cart. | Romance of the Three Kingdoms Model NES-IS-USA | 1989 | KOEI Corp. CA, USA |
| Nintendo NES cart. | Roundball - 2-on-2 Challenge Model NES-RW-USA | 1992 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| Nintendo NES cart. | Rupui Hb | 2015 | Arnpoly |
| Nintendo NES cart. | Rush'n Attack Model NES-RA-USA | 1987 | Konami, Inc. USA |
| Nintendo NES cart. | Russian Roulette Hb | 2014 | Yerrick, Damian |
| Nintendo NES cart. | Rygar Model NES-RY-EEC | 1989 | Tecmo, Ltd. Tokyo, Japan |
| Nintendo NES cart. | Rygar Model NES-RY-USA | 1987 | Tecmo, Inc. CA, USA |
| Nintendo NES cart. | S.C.A.T. - Special Cybernetic Attack Team Model NES-FV-USA | 1991 | Natsume, Inc. Burlingame, CA, USA |
| Nintendo NES cart. |  Scarabeus | 19?? | Unknown |
| Nintendo NES cart. | Secret Scout In The Temple of Demise | 1991 | Color Dreams, Inc. Brea, CA, USA |
| Nintendo NES cart. | Secret Ties | 1992 | Vic Tokai Japan |
| Nintendo NES cart. | Section Z Model NES-SZ-EEC | 1989 | Capcom Co., Ltd. Japan |
| Nintendo NES cart. | Section Z Model NES-SZ-USA | 1987 | Capcom USA, Inc. Santa Clara, CA, USA 13388 |
| Nintendo NES cart. | Seicross Model NES-SE-USA P | 1988 | FCI Fujisankei Communications International |
| Nintendo NES cart. | Sesame Street - Big Bird's Hide and Speak Model NES-4H-USA | 1990 | Hi-Tech Expressions, Inc. |
| Nintendo NES cart. | Sesame Street 123 Model NES-H3-USA | 1989 | Hi-Tech Expressions, Inc. |
| Nintendo NES cart. | Sesame Street ABC & 123 Model NES-5A-USA | 1991 | Hi-Tech Expressions, Inc. |
| Nintendo NES cart. | Sesame Street ABC Model NES-H4-USA | 1989 | Hi-Tech Expressions, Inc. |
| Nintendo NES cart. | Sesame Street Countdown Model NES-85-USA | 1992 | Hi-Tech Expressions, Inc. |
| Nintendo NES cart. | Shadow of the Ninja Model NES-27-USA | 1990 | Natsume, Inc. Burlingame, CA, USA |
| Nintendo NES cart. | Shadow Warriors II - The Dark Sword of Chaos | 1991 | Tecmo, Ltd. Tokyo, Japan |
| Nintendo NES cart. | Shadow Warriors Model NES-66-EUR | 1991 | Tecmo, Ltd. Tokyo, Japan |
| Nintendo NES cart. | Shadowgate Model NES-3S-FRA | 1991 | Kemco, Ltd. |
| Nintendo NES cart. | Shadowgate Model NES-3S-HOL | 1991 | Kemco, Ltd. |
| Nintendo NES cart. | Shadowgate Model NES-3S-NOE/FRG | 1992 | Kemco, Ltd. |
| Nintendo NES cart. | Shadowgate Model NES-3S-SWE | 1991 | Kemco, Ltd. |
| Nintendo NES cart. | Shadowgate Model NES-3S-USA | 1989 | Kemco-Seika USA |
| Nintendo NES cart. | Shatterhand Model NES-9H-USA | 1991 | JALECO USA, Inc. USA |
| Nintendo NES cart. | Shingen the Ruler Model NES-23-USA | 1990 | Hot-B USA, Inc. |
