| MSX cart. |  Yazzie Hb | 2019 | RetroSouls |
| MSX cart. | Yazzie Remastered Hb | 2020 | RetroSouls |
| MSX cart. | Yellow Submarine | 1987 | Brother Kougyou Japan |
| MSX cart. | Yellow Submarine | 1987 | Jast Japan |
| MSX cart. | Yie Ar Kung-Fu | 198? | MegaCom Taiwan |
| MSX cart. | Yie Ar Kung-Fu 2 Model SN-255 | 198? | MegaCom Taiwan |
| MSX cart. | Yie Ar Kung-Fu II - The Emperor Yie-Gah | 1985 | Topia Korea |
| MSX cart. | Yie Ar Kung-Fu II - Yie-Gah Koutei no Gyakushuu Model RC737 | 1985 | Konami Industry Co., Ltd. Japan |
| MSX cart. | Yie Ar Kung-Fu Model RC725 P | 1985 | Konami Industry Co., Ltd. Japan |
| MSX cart. | Yogoetamjeong Chimagun Chimachima | 198? | Topia Korea |
| MSX cart. | Youji no Eigo | 1983 | Stratford Computer Center Japan |
| MSX cart. | Youkai Tantei Chima Chima Model MK-7401 P | 1985 | Bothtec, Inc. Japan |
| MSX cart. | Youkai Yashiki Model GPM-123 | 1986 | Casio Computer Co., Ltd. |
| MSX cart. | Young Sherlock - Doyle no Isan | 1985 | Pack-In-Video Co., Ltd. Japan |
| MSX cart. | Yume Tairiku Adventure | 1988 | Screen Soft. Korea |
| MSX cart. | Yume Tairiku Adventure | 1987 | Zemina Korea |
| MSX cart. | Yume Tairiku Adventure Model RC743 | 1986 | Konami Industry Co., Ltd. Japan |
| MSX cart. | Yumetairiku Adventure Model CSG-074R | 198? | Clover Korea |
| MSX cart. | Z Hb | 2018 | Cobinee |
| MSX cart. | Z2 Hb | 2019 | Cobinee |
| MSX cart. | z80rogue Hb | 2019 | Nanochess |
| MSX cart. | Zanac A.I. 2nd Version Model R49X5093 | 1987 | Pony Canyon, Inc. Japan |
| MSX cart. | Zanac A.I. Model R49X5093 | 1985 | Pony Canyon, Inc. Japan |
| MSX cart. | Zaxxon Model J31 | 198? | Epcom Equipamentos Eletronicos da Amazonia, Ltda. Brazil |
| MSX cart. | Zaxxon Model R48X5803 | 1985 | Pony Canyon, Inc. Japan |
| MSX cart. | Zaxxon Model SN-234 | 198? | MegaCom Taiwan |
| MSX cart. | Zemmix Baduk Gyosil | 198? | Unknown Korea |
| MSX cart. | Zenji | 1984 | Pony Canyon, Inc. Japan |
| MSX cart. | ZERO and the Castle of Infinite Sadness | 2017 | Matra Computer Automations Spain |
| MSX cart. | ZERO and the Castle of Infinite Sadness Hb | 2014 | Dioniso |
| MSX cart. | Zexas Kousoku Limited Revolution Model MS1-G2109-P1 | 1985 | DB-SOFT Japan |
| MSX cart. | Zexas Kousoku Limited Revolution Model MS1-G2109-P2 | 1985 | DB-SOFT Japan |
| MSX cart. | Zombie Calavera Prologue Hb | 2021 | Nanochess |
| MSX cart. | Zombie Incident Hb | 2012 | Nenefranz |
| MSX cart. | Zombie Near Hb | 2011 | Nanochess |
| MSX cart. | Zone TNT Hb | 2011 | Gamecast Ent. |
| MSX cart. | Zoom 909 | 198? | ProSoft Korea |
| MSX cart. | Zoom 909 Model R49x5804 P | 1986 | Pony Canyon, Inc. Japan |
| MSX cart. | Zorni Exerion II | 198? | Aquarius Thailand |
| MSX cart. | Zorni Exerion II Model J26 | 198? | Epcom Equipamentos Eletronicos da Amazonia, Ltda. Brazil |
