| Handheld game |  Shark Hunter Model YG-263-A | 198? | Morioka Tokei, Inc. |
| Handheld game | Shark Island Model 16281 | 198? | Bandai Co., Ltd. Japan |
| Handheld game | Shark Island Model 60-2179 | 1984 | Tandy Corp. |
| Handheld game | Sharks | 198? | Masudaya Corp. Japan |
| Handheld game | Sherman Attack 3D | 1983 | Tomy |
| Handheld game | Shifty Model 7-525 | 1989 | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| Handheld game | Shinobi | 198? | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| Handheld game | Shuttle Bomber Model CG-70 | 1983 | Casio Computer Co., Ltd. |
| Handheld game | Shuttle Voyage Model MG8 | 198? | Tronica |
| Handheld game | Shuttle Voyage Model MG8 | 1983 | Sinitron |
| Handheld game | Sicom 16 | 1980 | Yonezawa Corp. Japan |
| Handheld game | Silbermedaille Model 7841 | 1983 | Gama Tronic |
| Handheld game | Silver Surfer | 1998 | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| Handheld game | Simon Model 4850-L1 | 1978 | MB Milton Bradley Co. East Longmeadow, MA, USA |
| Handheld game | Skate or Die | 1989 | Konami Co., Ltd. Japan |
| Handheld game | Skeet Shoot Model 7-743 | 1988 | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| Handheld game | Skeleton Warriors | 1994 | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| Handheld game | Ski Slalom Model 8290 | 1980 | Mattel Electronics Mattel, Inc. |
| Handheld game | Sky Attack 3D Model 7616 | 1983 | Tomy |
| Handheld game | Sky Invaders | 198? | POP Game |
| Handheld game | Slam Dunk | 1993 | Bandai Co., Ltd. Japan |
| Handheld game | Slam Dunk Basketball | 1995 | MGA Micro Games of America |
| Handheld game | Sleep Walker | 1981 | VTECH Video Technology, Ltd. |
| Handheld game | Sleeping Beauty | 198? | Hanimex |
| Handheld game | Sleeping Beauty Model SB-12 | 198? | Game & Time |
| Handheld game | Slimboy Baseball Quartz | 1983 | Tomy |
| Handheld game | Slimboy Ideon | 1982 | Tomy |
| Handheld game | Slimboy Racing 5 | 198? | Tomy |
| Handheld game | Slimboy Shooting 6 | 1981 | Tomy |
| Handheld game | Slimboy Spacequartz | 1982 | Tomy |
| Handheld game | Slimline Speedway Model 7605 | 1981 | Tomy |
| Handheld game | Slingo | 1998 | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| Handheld game | Slot Elepachi | 1983 | Tsukuda Original Japan |
| Handheld game | Slot Machine Model SM-801 | 198? | Unknown |
| Handheld game | Slot Model 60-2680 | 199? | Radio Shack Fort Worth, TX, USA |
| Handheld game | Smash T.V. Model 45007 | 1991 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Handheld game | Smurf Model 7-822 | 1984 | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| Handheld game | Sniper | 198? | Unknown |
| Handheld game | Snoopy Match Game | 198? | Canon |
| Handheld game | Snoopy Tennis | 198? | J.i 21 Jeux et Images du 21e siècle France |
