| Slot Machine |  Songs of Eros - Wonderful By Night | 2016 | Aristocrat Leisure Industries Pty, Ltd. |
| Apple tvOS pack. | Sonic CD P | 2016 | SEGA of America, Inc. San Francisco, CA, USA |
| Apple tvOS pack. | Sonic the Hedgehog | 2016 | Unknown |
| Apple tvOS pack. | Sonic the Hedgehog 2 | 2016 | Unknown |
| PC/MS-Windows pack. | Sorcerer King | 2016 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Sorcerer King - Rivals | 2016 | GOG sp. z o.o. |
| V.R. game | Soukou Kihei Votoms Battler | 2016 | Bandai NAMCO Ent., Inc. |
| Arcade Video game | Sound Voltex IV - Heavenly Haven | 2016 | Konami Digital Ent. Co., Ltd. |
| PC/MS-Windows CD | Space Hulk - Deathwing | 2016 | Focus Home Interactive S.A.S. |
| Dedicated Console | Space Invaders | 2016 | MSI Ent., LLC Florida, USA |
| PC/MS-Windows pack. | Space Rangers - Quest | 2016 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Space Rogue Classic | 2016 | GOG sp. z o.o. |
| Sinclair ZX Spectrum cass. | Specball Hb | 2016 | ZozoSoft |
| Slot Machine | Sphinx 3D | 2016 | IGT International Game Technologies Reno, NV, USA |
| Arcade Video game | Splash Motion Simulator | 2016 | Injoy Motion Corp. Taipei Country, Taiwan |
| PC/MS-Windows pack. | SPORE Collection | 2016 | GOG sp. z o.o. |
| MSX 2 disk | Spring Warrior | 2016 | Oniric Factor Spain |
| PC/MS-Windows pack. | Star Chart Model 460580 | 2016 | Steam Valve Corp. |
| Apple tvOS pack. | Star Horizon | 2016 | Unknown |
| Sony PlayStation 3 disc | Star Ocean 5 - Integrity and Faithlessness Model BLJM-61325 | 2016 | Square Enix Co., Ltd. Japan |
| Sony PlayStation 4 BR | Star Ocean 5 - Integrity and Faithlessness Model PLJM-84042 | 2016 | Square Enix Co., Ltd. Japan |
| PC/MS-Windows pack. | Star Trek - Starfleet Command - Gold Edition Model 364820 | 2016 | Steam Valve Corp. |
| Google Play pack. | Star Trek Timelines | 2016 | Tilting Point |
| PC/MS-Windows pack. | Star Vikings Forever | 2016 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Star Wars - Galactic Battlegrounds Saga Model 356500 | 2016 | Steam Valve Corp. |
| PC/MS-Windows pack. | Star Wars - Rebel Assault I + II Model 456540 | 2016 | Steam Valve Corp. |
| PC/MS-Windows pack. | Star Wars - Rebellion Model 441550 | 2016 | Steam Valve Corp. |
| PC/MS-Windows pack. | Star Wars - Rogue Squadron 3D Model 455910 | 2016 | Steam Valve Corp. |
| PC/MS-Windows pack. | Star Wars Shadows of the Empire | 2016 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Star Wolves 2 | 2016 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Star Wolves 3 - Civil War | 2016 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Starbound | 2016 | GOG sp. z o.o. |
| PC/MS-Windows CD | Starcraft II - Nova Covert Ops | 2016 | Blizzard Ent., Inc. |
| Commodore C64 disk | States of Brazil Hb | 2016 | Hart, Barry |
| PC/MS-Windows pack. | Steam Squad Model 290870 | 2016 | Steam Valve Corp. |
| PC/MS-Windows CD | Stellaris | 2016 | Paradox Interactive |
| PC/MS-Windows pack. | Stellaris Model 281990 | 2016 | Steam Valve Corp. |
| Apple tvOS pack. | Steppy Pants | 2016 | Unknown |
| PC/MS-Windows pack. | Stern Pinball Arcade Model 564010 | 2016 | Steam Valve Corp. |
| Google Play pack. | Stick War - Legacy | 2016 | Max Games Studios |
