| Redemption mechanical game |  Sea Wolf 55 | 2012 | Coastal Amusements, Inc. Lakewood, NJ, USA |
| Slot Machine | Secret Elixir | 2012 | AGI Austrian Gaming Industries Novomatic Group |
| PC/MS-Windows CD | Secret Files 3 | 2012 | Deep Silver, Inc. |
| Slot Machine | Secrets of Alchemy | 2012 | EGT Euro Games Technology, Ltd. Bulgaria |
| Slot Machine | Secrets of the Stars | 2012 | AGI Austrian Gaming Industries Novomatic Group |
| Arcade Video game | Sega Card-Gen MLB 2012 | 2012 | SEGA Corp. |
| Pachislot | Seka Mogu | 2012 | Net Corp. Japan |
| Sony PlayStation 3 disc | Sengoku Basara HD Collection Model BLJM-60488 | 2012 | Capcom Co., Ltd. Japan |
| Pachislot | Sengoku Pachislot Hana no Keiji - Ten ni Aisa Reshi Otoko | 2012 | Newgin Japan |
| Arcade Video game | Sengoku Taisen - 1582 Sun, Honnoji's Cheat | 2012 | SEGA Corp. |
| Arcade Video game | Sengoku Taisen - 15XX Five Men of Shishido | 2012 | SEGA Corp. |
| Pachislot | Senjin Uesugi Kenshin | 2012 | KPE Konami Group Japan |
| Slot Machine | Serengeti Diamonds Elite Class | 2012 | Rocket Gaming Systems |
| PC/MS-Windows pack. | Shadow Warrior Classic Complete | 2012 | GOG sp. z o.o. |
| Redemption mechanical game | Shark Hunter | 2012 | G-Look Amusement |
| Sony PSN: Shodai PS Archives pack. |  Sheep Model NPJI-????? | 2012 | GungHo Online Ent. |
| Dart game | Shelti Eye 2 | 2012 | Shelti |
| Dart game | Shelti RD | 2012 | Shelti |
| Slot Machine | Shen Long | 2012 | Aruze Gaming America, Inc. Las Vegas, NV, USA |
| Slot Machine | Sherlock Holmes - Fortune's Detective | 2012 | Aristocrat Leisure Industries Pty, Ltd. |
| Sony PlayStation 3 disc | Shin Hokuto Musou Model BLAS-50556 | 2012 | KOEI Co., Ltd. Japan |
| Sony PlayStation 3 disc | Shin Hokuto Musou Model BLJM-60553 | 2012 | KOEI Co., Ltd. Japan |
| Sony PlayStation 3 disc | Shin Sangoku Musou - MultiRaid 2 HD Version Model BLJM-85003 | 2012 | KOEI Co., Ltd. Japan |
| Sony PSN: Shodai PS Archives pack. | Shingata Kururin Pa! Model NPJJ-00632 | 2012 | Sky Think System |
| Slot Machine | Shining Crown | 2012 | EGT Euro Games Technology, Ltd. Bulgaria |
| Arcade Video game | Shining Force Cross Elysion | 2012 | SEGA Corp. |
| Arcade Video game | Shinkansen Hakodate DO? | 2012 | NAMCO Bandai Games, Inc. Japan |
| Sony PSN: Shodai PS Archives pack. | Shiritsu Justice Gakuen - Legion of Heroes Model NPJI-????? | 2012 | Capcom Co., Ltd. Japan |
| Sony PSP UMD | Shirokuma Bell Stars - Happy Holidays! Model ULJM-06111 | 2012 | Boost On Japan |
| PC/MS-Windows CD | Shirudaku Nobushito Black Box | 2012 | Black Lilith |
| PC/MS-Windows CD | Shoot Many Robots | 2012 | Ubisoft Ent. Montreuil sous Bois, France |
| PC/MS-Windows pack. | Sid Meier's Colonization | 2012 | GOG sp. z o.o. |
| Microsoft XBOX 360 disc | Silent Hill Downpour | 2012 | Konami Digital Ent. Co., Ltd. |
| Sony PlayStation 3 disc | Silent Hill Downpour Model BLUS-30565 | 2012 | Konami Digital Ent. Co., Ltd. |
| Microsoft XBOX 360 disc | Silent Hill HD Collection | 2012 | Konami Digital Ent. Co., Ltd. |
| Sony PlayStation 3 disc | Silent Hill HD Collection | 2012 | Konami Digital Ent. Co., Ltd. |
| PC/MS-Windows pack. | Silver | 2012 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Sins of a Solar Empire - Rebellion | 2012 | Stardock Ent. |
| Pachislot | Sister Quest III - Ougon no Daichi to Higashi no Yuusha | 2012 | SNK Playmore Japan |
| Google Play pack. | Six-Guns | 2012 | Gameloft S.A. France |
