| Sega Mega Drive cart. |  Ecco the Dolphin Model 1042-50 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD |  Ecco the Dolphin Model 4408 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | Ecco the Dolphin Model 4408 | 1996 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Master System cart. | Ecco the Dolphin Model 9029 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Game Gear cart. | Ecco the Dolphin Model G-3344 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ecco the Dolphin Model G-4106 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Egawa Suguru no Super League CD Model G-6019 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Pico game | Ein Jahr in Winnie Puuhs Leben Model 49021-18 | 199? | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega ST-V cart. | Ejihon Tantei Jimusyo | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Pico game | El Profesor Pico en el Mundo de los Colores Model 49041-06 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega SG-1000 game | Elevator Action Model C-55 | 1985 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Emergency Call Ambulance | 1999 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Game Gear cart. |  Empire Syndicate | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mark III cart. | Enduro Racer Model G-1322 | 1987 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Master System cart. | Enduro Racer Model MK-5077-50 | 1987 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Enduro Racer Sit-Down model | 1986 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Enduro Racer Upright model | 1986 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Enduro Racer Wheelie model | 1986 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Enemy Zero | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| PC/MS-Windows CD | Enemy Zero | 1998 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Enemy Zero Model 81076 | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega AI Computer cart. | English Wonder School: Eigo de Game - Popo's Adventure Model C-9533/C-9536 | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega AI Computer cart. | English Wonder School: Eigo de Ohanashi - Folk & Fairy Tales Model C-9532/C-9535 | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Erase Lo-Profil model | 1975 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Erase Upright model | 1975 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Escape from Mars Starring Taz | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | ESWAT - City Under Siege | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Eternal Champions - Challenge From the Dark Side Model 4427-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | Eternal Champions - Challenge from the Dark Side Model 4427 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Eternal Champions Model 1145-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Eternal Champions Model 1145 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Eternal Champions Model G-4114 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Game Gear cart. | Eternal Legend - Eien no Densetsu Meisaku Collection Model G-3412 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Game Gear cart. | Eternal Legend - Eien no Densetsu Model G-3402 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Pico game | Ett Ar med Nalle Puh | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Game Gear cart. | Evander Holyfield Boxing Model 2419-50 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Game Gear cart. | Evander Holyfield Boxing Model 2419 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Redemption mechanical game | EX UFO Catcher | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ex-Ranza Model G-4097 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Excite League Model 317-0079 | 1988 | SEGA Enterprises, Ltd. Tokyo, Japan |
