| Nintendo GameCube disc |  Ed, Edd n Eddy - The Mis-Edventures Model DOL-GE9E-USA | 2005 | Midway Home Ent. |
| Acorn BBC Micro B disk | Egghead in Space Hb | 2005 | Cronosoft |
| Slot Machine | Egyptian Queen | 2005 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Slot Machine | Egyptian Riches Monopoly - Big Event | 2005 | WMS Gaming, Inc. Chicago, IL, USA |
| Sony PSP UMD | Eiyuu Densetsu IV - Gagharv Trilogy - Akai Shizuku | 2005 | Bandai Co., Ltd. Japan |
| Nintendo DS cart. | Electroplankton Model NTR-ATIJ-JPN | 2005 | Nintendo Co., Ltd. Japan |
| Nintendo GBA cart. | Elemental Gerad - Tozasareshi Uta Model AGB-BEJJ-JPN | 2005 | Tomy |
| Slot Machine | Eleven | 2005 | Bally Wulff |
| Nintendo GBA cart. | Elf Bowling 1 & 2 Model AGB-BEBE-USA | 2005 | Ignition Ent., Ltd. |
| Nintendo DS cart. | Elf Bowling 1&2 Model NTR-AEBE-USA | 2005 | Ignition Ent., Ltd. |
| Slot Machine | Elizabeth Taylor - Dazzling Diamonds | 2005 | IGT International Game Technologies Reno, NV, USA |
| VTECH V.Smile cart. | Elmos großes Abenteuer | 2005 | VTECH Video Technology, Ltd. |
| Slot Machine | Emerald Forest | 2005 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Emerald Ring | 2005 | WMS Gaming, Inc. Chicago, IL, USA |
| Slot Machine | Emerald Rose | 2005 | IGT International Game Technologies Reno, NV, USA |
| PC/MS-Windows CD | Emergency 3 | 2005 | Strategy First |
| Slot Machine | Emperor's Palace | 2005 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Emperor's Palace Classic Blend Series | 2005 | EGT Euro Games Technology, Ltd. Bulgaria |
| PC/MS-Windows CD | Empire Earth II | 2005 | Vivendi Universal Games, Inc. |
| LeapFrog Leappad cart. | Englisch Kurs - Let's go 3 | 2005 | LeapFrog |
| LeapFrog Leappad cart. | Englisch Kurs - Let's go 4 | 2005 | LeapFrog |
| PC/MS-Windows CD | ER | 2005 | Vivendi Universal Games, Inc. |
| Arcade Video game | Espgaluda II | 2005 | Cave Co., Ltd. Japan |
| Pachislot | Evangelion | 2005 | Daido |
| Sony PlayStation 2 disc |  EVE - Burst Error Plus Model SLPM-65930 | 2005 | Game Village Japan |
| Nintendo GBA cart. | Ever Girl Model AGB-BEVE-USA | 2005 | T-HQ, Inc. Toy HeadQuarters |
| PC/MS-Windows CD | EverQuest - Depths of Darkhollow | 2005 | Sony Computer Ent. America SCEA CA, USA |
| PC/MS-Windows CD | EverQuest - Dragons of Norrath | 2005 | Sony Computer Ent. America SCEA CA, USA |
| PC/MS-Windows CD | Evil Dead - Regeneration | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Sony PSP UMD | Exit Model ULJM-05062 | 2005 | Taito Corp. Japan |
| Slot Machine | Extra Draw Keno | 2005 | IGT International Game Technologies Reno, NV, USA |
| Sega NAOMI GD-ROM |  ExZeus | 2005 | Taito Corp. Japan |
| Arcade Video game | Ez Touch Global | 2005 | IGS Co., Ltd. International Game System |
| PC/MS-Windows CD | F.E.A.R. | 2005 | Vivendi Universal Games, Inc. |
| Sony PSP UMD | F1 Grand Prix | 2005 | Sony Computer Ent. America SCEA CA, USA |
| PC/MS-Windows CD | Fable - The Lost Chapter | 2005 | Microsoft |
| PC/MS-Windows CD | Fahrenheit | 2005 | Atari Interactive, Inc. |
| Nintendo DS cart. | Famicom Wars DS | 2005 | Nintendo Co., Ltd. Japan |
| Tabletop game | Family Guy Stewie - Electronic Talking Pinball Model 403-A | 2005 | Excalibur Electronics, Inc. |
| Sony PlayStation 2 disc |  Famitsuu Gentei Taikenban: Armored Core - Last Raven Model SLPM-61118 | 2005 | From Soft. |
