Following the events of the first Ghostbusters (which included the confrontation with Gozer the Gozerian), things have been slow for the ghostbusters, until one day, an earthquake occurs which is followed by spikes in paranormal activity in New York, and with that it's up to Peter Venkman, Egon Spengler, and Raymond Stantz to bring order to not just the city, but the world as well.
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This game was released on June 29, 1990.
Some early Sega Genesis posters featured some beta screenshots of Ghostbusters under the name Ghostbusters II (which implicated that the game was loosely based on the 1989 film), however, the game kept the title as Ghostbusters, despite the game's storyline not having any connections to the movies (as it adopts an original story).