| Sega Genesis cart. |  RoadBlasters Model 31763-03250 | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | RoboCop 3 Model T-81226 | 1993 | Flying Edge |
| Sega Genesis cart. | RoboCop versus The Terminator Model T-70166 | 1994 | Virgin Games, Ltd. UK 013715 |
| Sega Genesis cart. | Robot Wreckage | 199? | Unknown |
| Sega Genesis cart. | Rock n' Roll Racing | 1994 | Interplay |
| Sega Genesis cart. |  Rocket Knight Adventures Model T-95046 | 1993 | Konami Co., Ltd. Japan |
| Sega Genesis cart. | Roger Clemens' MVP Baseball | 1992 | Flying Edge |
| Sega Genesis cart. | Rolling Thunder 2 Model T-14066 P | 1991 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | Rolling Thunder 3 Model T-14096 | 1993 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | Romance of the Three Kingdoms II Model T-76016 | 1991 | KOEI Corp. CA, USA |
| Sega Genesis cart. | Romance of the Three Kingdoms III - Dragon of Destiny | 1993 | KOEI Corp. CA, USA |
| Sega Genesis cart. | Rugby World Cup 95 Model 7413 | 1994 | EA Sports |
| Sega Genesis cart. | Saban's VR Troopers Model 1576 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sagaia Model 11016 | 1991 | Taito Corp. Japan |
| Sega Genesis cart. | Saint Sword | 1991 | Taito America Corp. Elk Grove Village, IL, USA |
| Sega Genesis cart. | Samurai Shodown Model T-103066 | 1994 | Takara USA Corp. New York, NY, USA 26483 |
| Sega Genesis cart. | Saturday Night Slammasters Model T-12066 | 1994 | Capcom USA, Inc. Santa Clara, CA, USA 13388 |
| Sega Genesis cart. | Scholastic's The Magic School Bus | 1995 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Scooby-Doo Mystery | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. |  Sea of Vengeance | 199? | Baton Technologies AZ, USA |
| Sega Genesis cart. | SeaQuest DSV Model T-100076 | 1994 | Black Pearl |
| Sega Genesis cart. |  Sega Classic: Golden Axe Model 1106C | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sega Club: The Berenstain Bears' Camping Adventure Model 1548 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Segapede | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sesame Street Counting Cafe Model T-50896 | 1994 | EA*Kids |
| Sega Genesis cart. | Shadow Blasters Model 47016 | 1990 | Sage's Creation, Inc. |
| Sega Genesis cart. | Shadow Dancer - The Secret of Shinobi Model 1114 | 1990 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Shadow of the Beast II Model 7164 | 1992 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Shadow of the Beast Model 7091 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Shadowrun Model 1352 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Shanghai II - Dragon's Eye | 1994 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Sega Genesis cart. | Shaq Fu Model 7283 | 1994 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Shining Force - The Legacy of Great Intention Model 1312 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Shining Force II Model 1315 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Shining in the Darkness Model 1310 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Shinobi III - Return of the Ninja Master Model 1136 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Ship | 199? | Technopop |
| Sega Genesis cart. | Shove It! ...The Warehouse Game Model T-25036 | 1990 | Dreamworks Games |
| Sega Genesis cart. | Side Pocket Model T-13046 | 1992 | Data East USA, Inc. |
| Sega Genesis cart. | Skeleton Krew Model T-115036 | 1995 | Core Design, Ltd. |
