| Sega Mega Drive cart. |  Eternal Champions Model 1145-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Eternal Champions Model 1145 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Eternal Champions Model G-4114 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Europa Sensen Model T-76113 | 1993 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | European Club Soccer | 1992 | Virgin Games, Ltd. UK 013715 |
| Sega Mega Drive cart. | Ex-Ranza Model G-4097 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Exile - Toki no Hazama he Model T-49093 | 1991 | Riot Japan |
| Sega Mega Drive cart. | Exo Squad Model T-70426-50 | 1995 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Mega Drive cart. | F-117 Stealth - Operation Night Storm Model EM20029 | 1994 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | F-15 Strike Eagle II Model T-104036-50 | 1993 | MicroProse, Ltd. Bristol, UK 015352 |
| Sega Mega Drive cart. | F-22 Interceptor | 1993 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | F1 | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | F1 Circus MD Model T-71013 | 1991 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Sega Mega Drive cart. | F1 World Championship Edition Model T-88146-50 | 1993 | Domark Group, Ltd. |
| Sega Mega Drive cart. | Fantasia Model 1021-50 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Fantasia Model G-4061 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Fantastic Dizzy | 1993 | Codemasters Soft. Co., Ltd., The 015026 |
| Sega Mega Drive cart. | Fastest 1 Model T-43023 | 1991 | Human Ent. Japan |
| Sega Mega Drive cart. | Fatal Fury P | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Fatal Labyrinth | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Fatal Rewind | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Fatal Rewind Model E183SMXI | 1991 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Fatman | 1990 | Sanritsu Japan |
| Sega Mega Drive cart. | Feng Kuang Tao Hua Yuan | 199? | Creaton Softech, Inc. Taiwan |
| Sega Mega Drive cart. | Feng Shen Ying Jie Chuan | 1996 | Chuanpu Technologies |
| Sega Mega Drive cart. | Ferrari Grand Prix Challenge | 1992 | Flying Edge |
| Sega Mega Drive cart. | Fever Pitch Soccer | 1995 | US Gold, Ltd. Birmingham, England 13442 |
| Sega Mega Drive cart. | Férias Frustradas do Pica-Pau | 1995 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | FIFA 98 - Road to World Cup | 1997 | EA Sports |
| Sega Mega Drive cart. | FIFA Soccer 95 | 1994 | EA Sports |
| Sega Mega Drive cart. | FIFA World Cup - South Africa 2010 | 199? | Unknown |
| Sega Mega Drive cart. | Fighting Masters Model T-24063 | 1991 | TRECO |
| Sega Mega Drive cart. | Final Blow Model T-11033 | 1990 | Taito Corp. Japan |
| Sega Mega Drive cart. | Fire Mustang Model T-11123 | 1991 | Taito Corp. Japan |
| Sega Mega Drive cart. | Fire Shark | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Flash Point P | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Flashback Model 79066 | 1993 | US Gold, Ltd. Birmingham, England 13442 |
| Sega Mega Drive cart. | Flashback Model T-15083 | 1993 | SUNSOFT Kounan, Japan |
| Sega Mega Drive cart. | Flicky | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Flicky | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
